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1

Characterization of the rat neurofibromatosis 2 gene and its involvement in asbestos-induced mesothelioma

Elena V. Kleymenova, Albert A. Bianchi, Nikolai Kley, Lev N. Pylev, Cheryl L. Walker

Journal:

Molecular Carcinogenesis

Year:

1997

Language:

english

File:

PDF, 211 KB

english, 1997

2

TP53 Gene Mutations and 17p Deletions in Human Astrocytomas

Richard Chung, Jean Whaley, Nikolai Kley, Kirstin Anderson, David Louis, Anil Menon, Claudia Hettlich, Richard Freiman, E. Tessa Hedley-Whyte, Robert Martuza, Robert Jenkins, David Yandell, Dr. Bernd

Journal:

Genes, Chromosomes and Cancer

Year:

1991

Language:

english

File:

PDF, 1.36 MB

english, 1991

3

Neurofibromatosis type 2 and von Hippel-Lindau disease: From gene cloning to function

Nikolai Kley, Jean Whaley, Bernd R. Seizinger

Journal:

Year:

1995

Language:

english

File:

PDF, 1.35 MB

english, 1995

4

Chemical Dimerizers and Three-Hybrid Systems: Scanning the Proteome for Targets of Organic Small Molecules

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 385 KB

english, 2004

5

A Proteome-Wide CDK/CRK-Specific Kinase Inhibitor Promotes Tumor Cell Death in the Absence of Cell Cycle Progression

Maureen Caligiuri, Frank Becker, Krishna Murthi, Faith Kaplan, Severine Dedier, Christine Kaufmann, Andy Machl, Gabriele Zybarth, Judson Richard, Nick Bockovich, Art Kluge, Nikolai Kley

Journal:

Chemistry & Biology

Year:

2005

Language:

english

File:

PDF, 631 KB

english, 2005

6

MASPIT: Three-Hybrid Trap for Quantitative Proteome Fingerprinting of Small Molecule-Protein Interactions in Mammalian Cells

Maureen Caligiuri, Lisa Molz, Qing Liu, Faith Kaplan, Jimmy P. Xu, Jiangwen Z. Majeti, Rebeca Ramos-Kelsey, Krishna Murthi, Sam Lievens, Jan Tavernier, Nikolai Kley

Journal:

Chemistry & Biology

Year:

2006

Language:

english

File:

PDF, 537 KB

english, 2006

7

The p53/IGF-1 receptor axis in the regulation of programmed cell death

Manfred Neuberg, Leonard Buckbinder, Bernd Seizinger, Nikolai Kley

Journal:

Endocrine (Springer)

Year:

1997

Language:

english

File:

PDF, 330 KB

english, 1997

8

Histamine Affects Release and Biosynthesis of Opioid Peptides Primarily via H1-Receptors in Bovine Chromaffin Cells

Michael Bommer, Daniel Liebisch, Nikolai Kley, Albert Herz, Ernest Noble

Journal:

Journal of Neurochemistry

Year:

1987

Language:

english

File:

PDF, 841 KB

english, 1987

9

Proenkephalin B Messenger RNA in Porcine Tissues: Characterization, Quantification, and Correlation with Opioid Peptides

Christoph W. Pittius, Nikolai Kley, Jean-Philippe Loeffler, Volker Höllt

Journal:

Journal of Neurochemistry

Year:

1987

Language:

english

File:

PDF, 919 KB

english, 1987

10

Induction of the growth inhibitor IGF-binding protein 3 by p53

Buckbinder, Leonard, Talbott, Randy, Velasco-Miguel, Susana, Takenaka, Ivone, Faha, Barbara, Seizinger, Bernd R., Kley, Nikolai

Journal:

Year:

1995

File:

PDF, 965 KB

1995

11

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

Velasco-Miguel, Susana, Buckbinder, Leonard, Jean, Patrice, Gelbert, Larry, Talbott, Randy, Laidlaw, Jana, Seizinger, Bernd, Kley, Nikolai

Journal:

Year:

1999

Language:

english

File:

PDF, 597 KB

english, 1999

12

Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity

Blankenship, Catherine, Naglich, Joseph G, Whaley, Jean M, Seizinger, Bernd, Kley, Nikolai

Journal:

Year:

1999

Language:

english

File:

PDF, 283 KB

english, 1999

13

The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control

Garkavtsev, Igor V, Kley, Nikolai, Grigorian, Irina A, Gudkov, Andrei V

Journal:

Year:

2001

Language:

english

File:

PDF, 351 KB

english, 2001

14

Cloning of a putative meningioma tumor suppressor gene

Peter H.J. Riegman, Ronald H. Lekanne Deprez, Nicole Groen, Ursula Kortenhorst, Anne Hagemeijer, Ellen van Drunen, Dirk Bootsma, Anil Menon, Nikolai Kley, Bernd R. Seizinger, Pieter de Jong, Ellen C.

Journal:

Cancer Genetics and Cytogenetics

Year:

1994

Language:

english

File:

PDF, 94 KB

english, 1994

15

A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF)

Yoichi Ohiro, Igor Garkavtsev, Shinichiro Kobayashi, Kodangattil R. Sreekumar, Regan Nantz, Bryan T. Higashikubo, Shannon L. Duffy, Ryuji Higashikubo, Anny Usheva, David Gius, Nikolai Kley, Nobuo Hori

Journal:

Year:

2002

Language:

english

File:

PDF, 2.69 MB

english, 2002

16

The von Hippel-Lindau Tumor Suppressor Protein Is Required for Proper Assembly of an Extracellular Fibronectin Matrix

Michael Ohh, Robert L. Yauch, Kim M. Lonergan, Jean M. Whaley, Anat O. Stemmer-Rachamimov, David N. Louis, Brian J. Gavin, Nikolai Kley, William G. Kaelin Jr., Othon Iliopoulos

Journal:

Year:

1998

Language:

english

File:

PDF, 398 KB

english, 1998

17

A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor

James A. Trofatter, Mia M. MacCollin, Joni L. Rutter, Jill R. Murrell, Mabel P. Duyao, Dilys M. Parry, Roswell Eldridge, Nikolai Kley, Anil G. Menon, Karen Pulaski, Volker H. Haase, Christine M. Ambro

Journal:

Year:

1993

Language:

english

File:

PDF, 1.77 MB

english, 1993

18

NF2 gene mutations in meningiomas and vestibular schwannomas

Ellen C. Zwarthoff, Albert B. Bianchi, Nicole A. Groen, Nikolai Kley, Bernd R. Seizinger, Anne Hagemeijer, Ellen van Drunen, Dirk Bootsma, Jan W. Koper, Cees J.J. Avezaat, Ronald H. Lekanne Deprez

Journal:

Cancer Genetics and Cytogenetics

Year:

1994

Language:

english

File:

PDF, 98 KB

english, 1994

19

Structure-Based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Zheng, Xiaozhang, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J., Caligiuri, Maureen, Clodfelter, Karl H., Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Lin, Jian, Reynolds, Dominic J., Sharma

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.06 MB

english, 2013

20

Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Zheng, Xiaozhang, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J., Caligiuri, Maureen, Clodfelter, Karl H., Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Lin, Jian, Reynolds, Dominic J., Sharma

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.27 MB

english, 2013

21

Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors

Zheng, Xiaozhang, Baumeister, Timm, Buckmelter, Alexandre J., Caligiuri, Maureen, Clodfelter, Karl H., Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Lin, Jian, Reynolds, Dominic J., Sharma, Geeta, Smit

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.28 MB

english, 2014

22

Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties

Gunzner-Toste, Janet, Zhao, Guiling, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J., Caligiuri, Maureen, Clodfelter, Karl H., Fu, Bang, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Liang, Xia

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 3.58 MB

english, 2013

23

The p53 Tumor Suppressor Targets a Novel Regulator of G Protein Signaling

Leonard Buckbinder, Susana Velasco-Miguel, Yan Chen, Ningzhi Xu, Randy Talbott, Larry Gelbert, Jizong Gao, Bernd R. Seizinger, J. Silvio Gutkind and Nikolai Kley

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.58 MB

english, 1997

24

Differentiation to a Neuronal Phenotype in Bovine Chromaffin Cells Is Repressed by Protein Kinase C and Is Not Dependent on c- fos Oncoproteins

DEMENEIX, BARBARA A., KLEY, NIKOLAI, LOEFFLER, JEAN-PHILIPPE

Journal:

DNA and Cell Biology

Year:

1990

Language:

english

File:

PDF, 16.94 MB

english, 1990

25

Exon scanning for mutation of the NF2 gene in schwannomas

Jacoby, Lee B., MacCollin, Mia, Louls, David N., Mohney, Trina, Rublo, Mari-Paz, Pulaski, Karen, Trofatter, James A., Kley, Nikolai, Seizinger, Bernd, Ramesh, Vijaya, Gusella, James F.

Journal:

Human Molecular Genetics

Year:

1994

Language:

english

File:

PDF, 4.12 MB

english, 1994

26

p53 Regulates Insulin-Like Growth Factor-I (IGF-I) Receptor Expression and IGF-I-Induced Tyrosine Phosphorylation in an Osteosarcoma Cell Line: Interaction between p53 and Sp1

Ohlsson, Claes, Kley, Nikolai, Werner, Haim, LeRoith, Derek

Journal:

Year:

1998

Language:

english

File:

PDF, 259 KB

english, 1998

27

Genomics and proteomics tools for compound mode-of-action studies in drug discovery

Kley, Nikolai, Ivanov, Igor, Meier-Ewert, Sebastian

Journal:

Pharmacogenomics

Year:

2004

Language:

english

File:

PDF, 122 KB

english, 2004

28

Repression of the basal c-fos promoter by wild-type p53

kley, Nikolai, chung, Richard Y., Fay, Sandra, Loeffler, Jean Philippe, Seizinger, Bernd R.

Journal:

Nucleic Acids Research

Year:

1992

Language:

english

File:

PDF, 1.05 MB

english, 1992

29

High Frequency of Inactivating Mutations in the Neurofibromatosis Type 2 Gene (NF2) in Primary Malignant Mesotheliomas

Albert B. Bianchi, Shin-Ichiro Mitsunaga, Jin Quan Cheng, Walter M. Klein, Suresh C. Jhanwar, Bernd Seizinger, Nikolai Kley, Andres J. P. Klein-Szanto and Joseph R. Testa

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 986 KB

english, 1995

30

Gene Regulation by Temperature-Sensitive p53 Mutants: Identification of p53 Response Genes

Leonard Buckbinder, Randy Talbott, Bernd R. Seizinger and Nikolai Kley

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.10 MB

english, 1994

31

Investigating the Molecular Basis of Drug Action and Response: Chemocentric Genomics and Proteomics

Zybarth, Gabriele, Kley, Nikolai

Journal:

Current Drug Targets

Year:

2006

Language:

english

File:

PDF, 56 KB

english, 2006

32

Dopamine Inhibition of Proopiomelanocortin Gene Expression in the Intermediate Lobe of the Pituitary

Loeffler, Jean-Philippe, Demeneix, Barbara A., Kley, Nikolai A., Höllt, Volker

Journal:

Neuroendocrinology

Year:

2008

File:

PDF, 1.40 MB

2008

33

In vivo and in vitro Studies of GABAergic Inhibition of Prolactin Biosynthesis

Loeffler, Jean-Philippe, Kley, Nikolai, Pittius, Christoph W., Almeida, Osborne F.X., Höllt, Volker

Journal:

Neuroendocrinology

Year:

1986

Language:

english

File:

PDF, 1.41 MB

english, 1986

34

Stress-Induced Alterations in the Levels of Messenger RNA Coding for Proopiomelanocortin and Prolactin in Rat Pituitary

Höllt, Volker, Przewłocki, Ryszard, Haarmann, Ingeborg, Almeida, Osborne F.X., Kley, Nikolai, Millan, Mark J, Herz, Albert

Journal:

Neuroendocrinology

Year:

1986

Language:

english

File:

PDF, 1.20 MB

english, 1986